After Initial Setback, IL-12 Regaining Popularity
نویسندگان
چکیده
منابع مشابه
In situ fusion for spondylolysis” is regaining its lost popularity
Abstract Background: Spondylolysis and spondylolisthesis can be associated with significant low back pain, especially in physically active adolescents. Non-operative management is usually successful in improving symptoms, but surgical intervention is occasionally required. The aim of this study was to determine the effect of in situ posterolateral fusion in the treatment of refractory cas...
متن کامل“In situ fusion for spondylolysis” is regaining its lost popularity
Background: Spondylolysis and spondylolisthesis can be associated with significant low back pain, especially in physically active adolescents. Non-operative management is usually successful in improving symptoms, but surgical intervention is occasionally required. The aim of this study was to determine the effect of in situ posterolateral fusion in the treatment of refractory cases with spondyl...
متن کاملin situ fusion for spondylolysis” is regaining its lost popularity
abstract background: spondylolysis and spondylolisthesis can be associated with significant low back pain, especially in physically active adolescents. non-operative management is usually successful in improving symptoms, but surgical intervention is occasionally required. the aim of this study was to determine the effect of in situ posterolateral fusion in the treatment of refractory case...
متن کاملResponses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18.
Interleukin-12 (IL-12) orchestrates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gamma interferon and, in turn, macrophage activation and parasite killing. Nevertheless, testing in IL-18(-/-) mice compared to wild-type mice and in IL-12p40(-/-) compared to IL-12p35(-/-) mice also suggested both early-acting (IL-18) and late-acting (IL-23) antileishma...
متن کاملTargeting the IL-12/IL-23 axis
Combination immune checkpoint blockade has demonstrated significant clinical responses in cancers infiltrated by T cells. Many tumors contain high proportions of myeloid cells and these can secrete immunosuppressive cytokines like IL-23. Our data suggest the clinical potential of using anti-CD40 (push) and anti-IL-23 mAbs (pull) to tip the IL-12/23 balance in established tumors and act as an al...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1996
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/88.9.576